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1

A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study

Tsai, Keng-Chang, Huang, Yi-Chia, Liaw, Chia-Ching, Tsai, Chia-I, Chiou, Chun-Tang, Lin, Chien-Jung, Wei, Wen-Chi, Lin, Sunny Jui-Shan, Tseng, Yu-Hwei, Yeh, Kuo-Ming, Lin, Yi-Ling, Jan, Jia-Tsrong, Li

Journal:

Biomedicine & Pharmacotherapy

Year:

2021

File:

PDF, 1.38 MB

2021

2

Serendipitous Discovery of Short Peptides from Natural Products as Tyrosinase Inhibitors

Hsiao, Nai-Wan, Tseng, Tien-Sheng, Lee, Yu-Ching, Chen, Wang-Chuan, Lin, Hui-Hsiung, Chen, Yun-Ru, Wang, Yeng-Tseng, Hsu, Hung-Ju, Tsai, Keng-Chang

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 7.11 MB

english, 2014

3

Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors

Yi-Ming Shao, Wen-Bin Yang, Hung-Pin Peng, Min-Feng Hsu, Keng-Chang Tsai, Tun-Hsun Kuo, Andrew H.-J. Wang, Po-Huang Liang, Chun-Hung Lin, An-Suei Yang, Chi-Huey Wong

Journal:

Year:

2007

Language:

english

File:

PDF, 185 KB

english, 2007

4

Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation

Tseng, Tien-Sheng, Tsai, Keng-Chang, Chen, Wang-Chuan, Wang, Yeng-Tseng, Lee, Yu-Ching, Lu, Chung-Kuang, Don, Ming-Jaw, Chang, Chang-Yu, Lee, Ching-Hsiao, Lin, Hui-Hsiung, Hsu, Hung-Ju, Hsiao, Nai-Wan

Journal:

Journal of Agricultural and Food Chemistry

Year:

2015

Language:

english

File:

PDF, 3.19 MB

english, 2015

5

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, Tien-Sheng, Chuang, Show-Mei, Hsiao, Nai-Wan, Chen, Yi-Wen, Lee, Yu-Ching, Lin, Chi-Chen, Huang, Cheng, Tsai, Keng-Chang

Journal:

Molecular BioSystems

Year:

2016

Language:

english

File:

PDF, 4.82 MB

english, 2016

6

Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model

Chen, Chen-Yu, Huang, Chi-Chang, Tsai, Keng-Chang, Huang, Wei-Jan, Huang, Wen-Ching, Hsu, Yu-Chen, Hsu, Feng-Lin

Journal:

Evidence-based Complementary and Alternative Medicine

Year:

2014

Language:

english

File:

PDF, 996 KB

english, 2014

7

Astragalus membranaceusâDerived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

Chang, Fu-Ling, Tsai, Keng-Chang, Lin, Tsai-Yu, Yang, Tz-Wen, Lo, Yan-Ni, Chen, Wang-Chuan, Chang, Jui-Hsien, Lu, Mei-Kuang, Chiou, Chun-Tang, Chen, Po-Hung, Yen, Yun, Pan, Shiow-Lin, Lee, Yu-Ching

Journal:

BioMed Research International

Year:

2020

Language:

english

File:

PDF, 1.82 MB

english, 2020

8

Discovery of a Novel Family of SARS-CoV Protease Inhibitors by Virtual Screening and 3D-QSAR Studies

Tsai, Keng-Chang, Chen, Shih-Yuan, Liang, Po-Huang, Lu, I-Lin, Mahindroo, Neeraj, Hsieh, Hsing-Pang, Chao, Yu-Sheng, Liu, Lincoln, Liu, Donald, Lien, Wei, Lin, Thy-Hou, Wu, Su-Ying

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 1.12 MB

english, 2006

9

A Ligand-Based Molecular Modeling Study on Some Matrix Metalloproteinase-1 Inhibitors Using Several 3D QSAR Techniques.

Keng-Chang Tsai, Thy-Hou Lin

Journal:

Year:

2004

File:

PDF, 7 KB

2004

10

Single chain antibody fragment with serine protease inhibitory property capable of neutralizing toxicity of Trimeresurus mucrosquamatus venom

Lee, Yu-Ching, Chen, Wang-Chuan, Liang, Meng-Huei, Lee, Chi-Hsin, Tsai, Keng-Chang, Chiang, Jen-Ron, Chiang, Liao-Chun, Chen, Chi-Ching, Chang, Chang-Yu, Lee, Ching-Hsiao, Leu, Sy-Jye, Yang, Yi-Yuan

Journal:

Biochemical and Biophysical Research Communications

Year:

2015

Language:

english

File:

PDF, 1.55 MB

english, 2015

11

Design and Synthesis of 3-Benzylaminocoumarin-7-O-Sulfamate Derivatives as Steroid Sulfatase Inhibitors

Hng, Yue, Lin, Mei-Hsiang, Lin, Tzung-Sheng, Liu, I-Chen, Lin, I-Chun, Lu, Yeh-Lin, Chang, Chiao-Nien, Chu, Pei-Fang, Tsai, Keng-Chang, Chen, Mei-Jou, Liang, Pi-Hui

Journal:

Bioorganic Chemistry

Year:

2020

Language:

english

File:

PDF, 723 KB

english, 2020

12

Isolation of anti-VEGF monoclonal antibodies with neutralizing effects from an Astragalus-induced immune antibody library

Lee, Yu-Ching, Huang, Hsien-Te, Chang, Chao-Di, Chen, Chin-Tien, Lin, Tsai-Yu, Yang, Tz-Wen, Chang, Fu-Ling, Lu, Mei-Kuang, Chiou, Chun-Tang, Chen, Wang-Chuan, Pan, Shiow-Lin, Tsai, Keng-Chang

Journal:

International Immunopharmacology

Year:

2020

File:

PDF, 3.75 MB

2020

13

Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification

Lü-Pei Du, Min-Yong Li, Keng-Chang Tsai, Qi-Dong You, Lin Xia

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 1.46 MB

english, 2005

14

Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq.

Sheng-Yang Wang, Ching-Ping Tseng, Keng-Chang Tsai, Chia-Fan Lin, Ching-Ya Wen, Hsin-Sheng Tsay, Naoya Sakamoto, Chin-Hsiao Tseng, Ju-Chien Cheng

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 563 KB

english, 2009

15

Supervised Feature Ranking Using a Genetic Algorithm Optimized Artificial Neural Network

Lin, Thy-Hou, Chiu, Shih-Hau, Tsai, Keng-Chang

Journal:

Journal of Chemical Information and Modeling

Year:

2006

Language:

english

File:

PDF, 116 KB

english, 2006

16

Pharmacophore identification of α1A-adrenoceptor antagonists

Min-Yong Li, Keng-Chang Tsai, Lin Xia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 223 KB

english, 2005

17

Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors

Hong, Bei-Tao, Chen, Chun-Lin, Fang, Jim-Min, Tsai, Keng-Chang, Wang, Shi-Yun, Huang, Wen-I, Cheng, Yih-Shyun E., Wong, Chi-Huey

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 763 KB

english, 2014

18

GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice

Wang, Yea-Hwey, Liou, Kuo-Tong, Tsai, Keng-Chang, Liu, Hui-Kang, Yang, Li-Ming, Chern, Chang-Ming, Shen, Yuh-Chiang

Journal:

Toxicology and Applied Pharmacology

Year:

2018

Language:

english

File:

PDF, 63.13 MB

english, 2018

19

Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease

Lu, I-Lin, Mahindroo, Neeraj, Liang, Po-Huang, Peng, Yi-Hui, Kuo, Chih-Jung, Tsai, Keng-Chang, Hsieh, Hsing-Pang, Chao, Yu-Sheng, Wu, Su-Ying

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 389 KB

english, 2006

20

Differential inhibition of CYP1-catalyzed regioselective hydroxylation of estradiol by berberine and its oxidative metabolites

Chang, Yu-Ping, Huang, Chiung-Chiao, Shen, Chien-Chang, Tsai, Keng-Chang, Ueng, Yune-Fang

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 1.58 MB

english, 2015

21

New Hirsutinolide-Type Sesquiterpenoids from Vernonia cinerea Inhibit Nitric Oxide Production in LPS-Stimulated RAW264.7 Cells

Kuo, Li-Ming, Tseng, Pei-Yi, Lin, Yu-Chi, Liaw, Chia-Ching, Zhang, Li-Jie, Tsai, Keng-Chang, Lin, Zhi-Hu, Ho, Hsiu-O, Kuo, Yao-Haur

Journal:

Year:

2018

Language:

english

File:

PDF, 187 KB

english, 2018

22

Characterizing structure–function relationship reveals mode of action of a novel antimicrobial peptide, P1, from jumper ant Myrmecia pilosula

Tseng, Tien-Sheng, Tsai, Keng-Chang, Chen, Chinpan

Journal:

Molecular BioSystems

Year:

2017

Language:

english

File:

PDF, 2.16 MB

english, 2017

23

Modeling Ligand—Receptor Interaction for Some MHC Class II HLA-DR4 Peptide Mimetic Inhibitors Using Several Molecular Docking and 3D QSAR Techniques.

Hsin-Yuan Wei, Keng-Chang Tsai, Thy-Hou Lin

Journal:

Year:

2005

File:

PDF, 8 KB

2005

24

Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses

Wen-Hsien Wen, Shi-Yun Wang, Keng-Chang Tsai, Yih-Shyun E. Cheng, An-Suei Yang, Jim-Min Fang, Chi-Huey Wong

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.60 MB

english, 2010

25

Pharmacophore Mapping for Kv1.5 Potassium Channel Blockers

Qian Yang, Lupei Du, Keng-Chang Tsai, Xiaojian Wang, Minyong Li, Qidong You

Journal:

Molecular Informatics

Year:

2009

Language:

english

File:

PDF, 670 KB

english, 2009

26

Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses

Hsu, Peng-Hao, Chiu, Din-Chi, Wu, Kuan-Lin, Lee, Pei-Shan, Jan, Jia-Tsrong, Cheng, Yih-Shyun E., Tsai, Keng-Chang, Cheng, Ting-Jen, Fang, Jim-Min

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

27

The effect of different electrostatic potentials on docking accuracy: A case study using DOCK5.4

Keng-Chang Tsai, Sheng-Hung Wang, Nai-Wan Hsiao, Minyong Li, Binghe Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 179 KB

english, 2008

28

Prediction of Carbohydrate Binding Sites on Protein Surfaces with 3-Dimensional Probability Density Distributions of Interacting Atoms

Tsai, Keng-Chang, Jian, Jhih-Wei, Yang, Ei-Wen, Hsu, Po-Chiang, Peng, Hung-Pin, Chen, Ching-Tai, Chen, Jun-Bo, Chang, Jeng-Yih, Hsu, Wen-Lian, Yang, An-Suei, Porollo, Aleksey

Journal:

Year:

2012

Language:

english

File:

PDF, 3.31 MB

english, 2012

29

Interaction of S17 Antibody with the Functional Binding Region of the Hepatitis B Virus Pre-S2 Epitope

Chang, Chang-Yu, Chang, Fu-Ling, Chiang, Chen-Wei, Lo, Yan-Ni, Lin, Tsai-Yu, Chen, Wang-Chuan, Tsai, Keng-Chang, Lee, Yu-Ching

Journal:

Viral Immunology

Year:

2018

Language:

english

File:

PDF, 802 KB

english, 2018

30

The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents

Lü-Pei Du, Keng-Chang Tsai, Min-Yong Li, Qi-Dong You, Lin Xia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 376 KB

english, 2004

31

Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics

Li, Ang, Yang, Duxiao, Zhu, Mengyuan, Tsai, Keng-chang, Xiao, Kun-hong, Yu, Xiao, Sun, Jinpeng, Du, Lupei

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

32

The first pharmacophore model for potent NF-κB inhibitors

Keng-Chang Tsai, Li-Wei Teng, Yi-Ming Shao, Yu-Chen Chen, Yu-Ching Lee, Minyong Li, Nai-Wan Hsiao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 571 KB

english, 2009

33

Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto: A novel nucleophilic catalytic mechanism for nattokinase

Zhong-liang Zheng, Zhen-yu Zuo, Zhi-gang Liu, Keng-chang Tsai, Ai-fu Liu, Guo-lin Zou

Journal:

Journal of Molecular Graphics and Modelling

Year:

2005

Language:

english

File:

PDF, 561 KB

english, 2005

34

Metabolomics study of Buyang Huanwu Tang Decoction in ischemic stroke mice by1H NMR

Chen, Hong-Jhang, Shen, Yuh-Chiang, Lin, Chin-Yu, Tsai, Keng-Chang, Lu, Chung-Kuang, Shen, Chien-Chang, Lin, Yun-Lian

Journal:

Year:

2012

Language:

english

File:

PDF, 581 KB

english, 2012

35

Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors

Wang, Peng-Cheng, Fang, Jim-Min, Tsai, Keng-Chang, Wang, Shi-Yun, Huang, Wen-I, Tseng, Yin-Chen, Cheng, Yih-Shyun E., Cheng, Ting-Jen Rachel, Wong, Chi-Huey

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.42 MB

english, 2016

36

Peramivir conjugates as orally available agents against influenza H275Y mutant

Wang, Peng-Cheng, Chiu, Din-Chi, Jan, Jia-Tsrong, Huang, Wen-I., Tseng, Yin-Chen, Li, Ting-Ting, Cheng, Ting-Jen, Tsai, Keng-Chang, Fang, Jim-Min

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.74 MB

english, 2017

37

Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors

Tseng, Tien-Sheng, Lee, Yu-Ching, Hsiao, Nai-Wan, Liu, Yun-Ru, Tsai, Keng-Chang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

38

Corrigendum to “A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors” [Eur. J. Med. Chem. 43 (2008) 1603–1611]

I.-Lin Lu, Keng-Chang Tsai, Yi-Kun Chiang, Weir-Torn Jiaang, Ssu-Hui Wu, Neeraj Mahindroo, Chia-Hui Chien, Shiow-Ju Lee, Xin Chen, Yu-Sheng Chao, Su-Ying Wu

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 170 KB

english, 2009

39

A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity

Shie, Jiun-Jie, Fang, Jim-Min, Lai, Po-Ting, Wen, Wen-Hsien, Wang, Shi-Yun, Cheng, Yih-Shyun E., Tsai, Keng-Chang, Yang, An-Suei, Wong, Chi-Huey

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 2.20 MB

english, 2011

40

Modeling Ligand−Receptor Interaction for Some MHC Class II HLA-DR4 Peptide Mimetic Inhibitors Using Several Molecular Docking and 3D QSAR Techniques

Wei, Hsin-Yuan, Tsai, Keng-Chang, Lin, Thy-Hou

Journal:

Journal of Chemical Information and Modeling

Year:

2005

Language:

english

File:

PDF, 908 KB

english, 2005

41

Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus

Chiu, Din-Chi, Lin, Tzu-Chen, Huang, Wen-I, Cheng, Ting-Jen R., Tsai, Keng-Chang, Fang, Jim-Min

Journal:

Organic & Biomolecular Chemistry

Year:

2017

Language:

english

File:

PDF, 1.01 MB

english, 2017

42

Factor Xa Active Site Substrate Specificity with Substrate Phage Display and Computational Molecular Modeling

Hsu, Hung-Ju, Tsai, Keng-Chang, Sun, Yi-Kun, Chang, Hung-Ju, Huang, Yi-Jen, Yu, Hui-Ming, Lin, Chun-Hung, Mao, Shi-Shan, Yang, An-Suei

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1003 KB

english, 2008

43

How to Generate Reliable and Predictive CoMFA Models

Zhang, Lei, Tsai, Keng-Chang, Du, Lupei, Fang, Hao, Li, Minyong, Xu, Wenfang

Journal:

Current Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 240 KB

english, 2011

44

A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies

Keng-Chang Tsai, Yu-Chen Chen, Nai-Wan Hsiao, Chao-Li Wang, Chih-Lung Lin, Yu-Ching Lee, Minyong Li, Binghe Wang

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 787 KB

english, 2010

45

Isolation, Characterization, and Molecular Modeling of a Rheumatoid Factor from a Hepatitis C Virus Infected Patient with Sjögren’s Syndrome

Lee, Yu-Ching, Tsai, Keng-Chang, Leu, Sy-Jye, Wang, Tuan-Jen, Liu, Chia-Yu, Yang, Yi-Yuan

Journal:

The Scientific World JOURNAL

Year:

2013

Language:

english

File:

PDF, 22.49 MB

english, 2013

46

Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: Selectivity, kinetic characterization, and molecular modeling

Lo, Sheng-Nan, Chang, Yu-Ping, Tsai, Keng-Chang, Chang, Chia-Yu, Wu, Tian-Shung, Ueng, Yune-Fang

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.00 MB

english, 2013

47

Protein–DNA complex-guided discovery of the antibacterial lead E1 for restoring the susceptibility of Klebsiella Pneumoniae to polymyxin B by targeting the response regulator PmrA

Tseng, Tien-Sheng, Tu, I-Fan, Chen, Hsiao-Ting, Lin, Lie-Chwen, Tsai, Keng-Chang, Wu, Shih-Hsiung, Chen, Chinpan

Journal:

Chemical Communications

Year:

2018

Language:

english

File:

PDF, 1.15 MB

english, 2018

48

Tamiphosphor monoesters as effective anti-influenza agents

Chen, Chun-Lin, Lin, Tzu-Chen, Wang, Shi-Yun, Shie, Jiun-Jie, Tsai, Keng-Chang, Cheng, Yih-Shyun E., Jan, Jia-Tsrong, Lin, Chun-Jung, Fang, Jim-Min, Wong, Chi-Huey

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

49

Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO

Tsay, Huey-Jen, Huang, Yung-Cheng, Chen, Yi-Jen, Lee, Yun-Hao, Hsu, Shu-Meng, Tsai, Keng-Chang, Yang, Cheng-Ning, Huang, Fong-Lee, Shie, Feng-Shiun, Lee, Lin-Chien, Shiao, Young-Ji

Journal:

Journal of Biomedical Science

Year:

2016

Language:

english

File:

PDF, 2.48 MB

english, 2016

50

Validation of the cognitively normal range and below normal range subtypes in chronically hospitalized patients with schizophrenia

Chiang, Shih-Kuang, Ni, Ching-Huan, Tsai, Chih-Pu, Lin, Keng-Chang

Journal:

Schizophrenia Research: Cognition

Year:

2016

Language:

english

File:

PDF, 813 KB

english, 2016

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